INDIVIDUAL SERUM-PROTEINS AND ACUTE PHASE REACTANTS IN MONOCLONAL IMMUNOGLOBULINOPATHIES (A STUDY IN PATIENTS WITH IGG MYELOMA)

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (2) , 189-196
Abstract
In 92 patients with multiple myeloma and Ig[immunoglobulin]G monoclonal proteinemia concentrations of 17 different serum proteins were specifically determined. Prealbumin, albumin, .alpha.2HS-glycoprotein, .alpha.2-macroglobulin, transferrin and IgA, IgM and IgD were significantly decreased in patients with IgG myeloma. The mean levels for the typical acute phase proteins, i.e., haptoglobin, orosomucoid and CRP [C-reactive protein] were significantly elevated. No significant differences were demonstrated for less typical acute phase proteins, i.e., .alpha.1-antitrypsin, ceruloplasmin and C3 [3rd component of complement] as well as for hemopexin and .beta.2-glycoprotein I. CRP values were strongly elevated in some sera, however in most patients they were within the normal limits. There was a negative correlation between monoclonal IgG and most of the studied proteins, including IgA, IgM and IgD. No correlation was demonstrated between the monoclonal IgG and the triad of typical acute phase proteins. Positive correlation was found between monoclonal IgG and the total serum protein and among the proteins negatively correlated with monoclonal IgG as well as among the individual acute phase proteins. Explanation of the correlations reported was suggested.

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