Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma1
Open Access
- 1 July 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 8 (3) , 215-226
- https://doi.org/10.1215/15228517-2006-004
Abstract
We have evaluated the efficacy of the multinuclear platinum chemotherapeutics BBR3464, BBR3571, and BBR3610 against glioma cells in culture and animaKeywords
This publication has 42 references indexed in Scilit:
- Synthesis, Characterization, and Cytotoxicity of a Novel Highly Charged Trinuclear Platinum Compound. Enhancement of Cellular Uptake with ChargeInorganic Chemistry, 2005
- Akt Activation Suppresses Chk2-Mediated, Methylating Agent–Induced G2 Arrest and Protects from Temozolomide-Induced Mitotic Catastrophe and Cellular SenescenceCancer Research, 2005
- Phase II studies of BBR3464, a novel tri-nuclear platinum complex, in patients with gastric or gastro-oesophageal adenocarcinomaEuropean Journal Of Cancer, 2004
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib TherapyScience, 2004
- Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to GefitinibNew England Journal of Medicine, 2004
- Cisplatin: mode of cytotoxic action and molecular basis of resistanceOncogene, 2003
- Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H, 1H−15N Gradient Heteronuclear Single-Quantum Coherence, and 195Pt) NMR SpectroscopyInorganic Chemistry, 2003
- Validating survivin as a cancer therapeutic targetNature Reviews Cancer, 2003
- A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464JBIC Journal of Biological Inorganic Chemistry, 2002
- Response of brain tumors to chemotherapy, evaluated in a clinically relevant xenograft modelJournal of Neuro-Oncology, 1995