Comparison of Antibodies as Molecular Recognition Elements for Biosensor Design
- 1 November 1988
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 21 (11) , 1947-1967
- https://doi.org/10.1080/00032718808059883
Abstract
Antibodies are studied in terms of their properties as molecular recognition elements using an antigen monitoring biosensor as a means of examining sensitivity and selectivity. This approach requires only a small amount of antibody for study and is illustrated for a model system in which two monoclonal antibodies and one polyclonal antibody to 2,4-dinitrophenol are compared on the basis of their association constants and cross-reactivity patterns with heterologous haptens.Keywords
This publication has 7 references indexed in Scilit:
- Monoclonal Antibody Biosensor for Antigen MonitoringAnalytical Letters, 1987
- Antibody response of polymer membrane electrodes incorporating antigenic ionophoresJournal of Membrane Science, 1987
- The accessibility of protein-bound dinitrophenyl groups to univalent fragments of anti-dinitrophenyl antibodyBiochemical Journal, 1976
- Thermodynamics of the binding of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl haptens to the homologous and heterologous rabbit antibodiesBiochemistry, 1972
- Kinetic and equilibrium studies on 2,4-dinitrophenyl hapten-antibody systemsImmunochemistry, 1968
- Variations in Affinities of Antibodies during the Immune Response*Biochemistry, 1964
- Handbook of Analytical ChemistrySoil Science, 1963