Conduction Delay from Purkinje Fiber to Ventricular Muscle Studied with Extracellular Microelectrodes

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Abstract
The relationship between electrical activity recorded intracellularly and extracellularly was studied in canine right ventricle. When the tip of a microelectrode was placed against a Purkinje fiber the electrical activity obtained had two components. The first component was a sharp diphasic wave which was defined as an action current while the second component was a rounded and flat diphasic wave which was defined as a field potential. Transmembrane action potentials recorded at the same site indicated that the first component was an active membrane current of the Purkinje fiber while the second component was identified as the field effect potential generated by ventricular fibers lying directly under the layer of Purkinje fibers. In areas where the Purkinje fibers were absent only the second component was present. The time delay of approximately 5 ms between the two components represents the conduction delay of the impulse from the Purkinje fiber to the ventricular fiber.

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