Reduced Chronic Hemolysis during High-Dose Vitamin E Administration in Mediterranean-Type Glucose-6-Phosphate Dehydrogenase Deficiency

Publisher Website
Google Scholar
Abstract
The observation that high-dose oral vitamin E supplementation (800 IU per day) improved red-cell survival in two rare disorders associated with increased red-cell susceptibility to oxidative stress prompted a similar trial in 23 patients with Mediterranean glucose-6-phosphate dehydrogenase (G6PD) deficiency. Three months of vitamin E administration resulted in decreased chronic hemolysis as evidenced by improved red-cell life span (P<0.025), with an improvement in red-cell half-life from 22.9±0.7 days to 25.1 ±0.6 days (mean ±S.E.M.), increased hemoglobin concentration (P<0.001), and decreased reticulocytosis (P<0.001) as compared with base-line values. Evaluation after one year of vitamin E administration demonstrated sustained improvement in all these indexes. Controlled clinical trials of vitamin E supplementation may be warranted to examine its efficacy in ameliorating acute hemolytic crises or in reducing morbidity from neonatal jaundice in this relatively common genetic disorder. (N Engl J Med. 1980; 303:416–20.)