Immunoreactive Glucagon in Nondiabetic and Diabetic Macaca Nigra
- 23 April 1981
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 13 (04) , 203-206
- https://doi.org/10.1055/s-2007-1019221
Abstract
The primary form of immunoreactive glucagon (IRG) in Macaca nigra has been identified as pancreatic, alpha-cell-size glucagon (IRG3500), with a molecular weight of about 3500. Assays with 30K and K-964 glucagon antibodies gave virtually identical results. Column chromatography of plasma on Bio-Gel P-30 indicated only minimal amounts of high-molecular-weight IRG. Levels of IRG decrease during a glucose infusion, a response expected of IRG3500. IRG concentrations apparently greater than human values appear to be characteristic of nonhuman primates. Nondiabetic Macaca nigra average 641 pg of IRG3500/ml. Border-line diabetic monkeys with moderately increased glucose and impaired glucose clearance average 2,938 pg/ml. Diabetic monkeys with hyperglycemia and diminished glucose clearance have 375 pg of IRG3500/ml. Changes in IRG3500 are related to a lesion in the islets of Langerhans.Keywords
This publication has 1 reference indexed in Scilit:
- Serumglucagon - What is It?Hormone and Metabolic Research, 1978