Mammalian Brain Alkaline Phosphatase: Expression of Liver/Bone/Kidney Locus Comparison of Fetal and Adult Activities

Publisher Website
Google Scholar
Abstract
The alkaline phosphatases (EC 3.1.3.1) are determined by at least 3 gene loci, which are distinguished one from another by their sensitivity to inhibition with various amino acids and peptides and by thermostability. Alkaline phosphatase is present in the brains of guinea pig, rat, mouse, hamster, squirrel, rabbit, cat, sheep, cow, tamarin, baboon and man. The gene locus coding for alkaline phosphatase in all these brains is the liver/bone/kidney locus, as indicated by thermostability and inhibition with L-phenylalanine, L-homoarginine and L-phenylalanylglycylglycine. The average brain alkaline phosphatase activity is .apprx. 35% of the average for the livers and only 7.2 and 4.4% of the average kidney and placental activities, respectively. During growth and development, brain alkaline phosphatase activity decreases in these mammals. The amount of change is tissue- and species-dependent.