PREGNANCY-SPECIFIC BETA-GLYCOPROTEIN IN COMPLICATIONS OF EARLY-PREGNANCY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 1  (8170) , 667-668
Abstract
Maternal concentrations of pregnancy-specific .beta.1-glycoprotein (SP1) were measured in 145 patients with vaginal bleeding in the 1st trimester of pregnancy. The levels of SP1 were substantially reduced in cases in which the outcome was unsatisfactory. The sensitivity of the test was 65%, the predictive value 96% and the specificity 98%; these results are at least as good as those of other biochemical tests of this type. Measurement of SP1 is evidently useful in diagnosis, even when ultrasound findings are also available. In a small group of subjects ultrasound and biochemical findings were normal, despite an unfavorable outcome, and it seems likely that such cases are beyond the reach of any present diagnostic measure.

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