Error Threshold for Spatially Resolved Evolution in the Quasispecies Model
- 18 June 2001
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 86 (25) , 5819-5822
- https://doi.org/10.1103/physrevlett.86.5819
Abstract
The error threshold for quasispecies in 1, 2, 3, and dimensions is investigated by stochastic simulation and analytically. The results show a monotonic decrease in the maximal sustainable error probability with decreasing diffusion coefficient, independently of the spatial dimension. It is thereby established that physical interactions between sequences are necessary in order for spatial effects to enhance the stabilization of biological information. The analytically tractable behavior in an -dimensional (simplex) space provides a good guide to the spatial dependence of the error threshold in lower dimensional Euclidean space.
Keywords
This publication has 17 references indexed in Scilit:
- Error Thresholds for Quasispecies on Dynamic Fitness LandscapesPhysical Review Letters, 2000
- Ising Quantum Chain is Equivalent to a Model of Biological EvolutionPhysical Review Letters, 1997
- The Importance of Being Discrete (and Spatial)Theoretical Population Biology, 1994
- Error thresholds of replication in finite populations mutation frequencies and the onset of muller's ratchetJournal of Theoretical Biology, 1989
- A localization threshold for macromolecular quasispecies from continuously distributed replication ratesThe Journal of Chemical Physics, 1984
- A stochastic theory of macromolecular evolutionBiological Cybernetics, 1984
- Self-replication with errorsBiophysical Chemistry, 1982
- Selforganization of matter and the evolution of biological macromoleculesThe Science of Nature, 1971
- Stochastic Models for Second-Order Chemical Reaction Kinetics. The Equilibrium StateThe Journal of Chemical Physics, 1966
- Absence of Diffusion in Certain Random LatticesPhysical Review B, 1958