ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin
Open Access
- 1 February 2008
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 31 (2) , 363-371
- https://doi.org/10.1183/09031936.00060207
Abstract
Ventilator-induced lung injury is characterised by inflammation and apoptosis, but the underlying mechanisms are poorly understood. The present study proposed a role for angiotensin-converting enzyme (ACE) via angiotensin II (Ang II) and/or bradykinin in acute lung injury. The authors assessed whether ACE and, if so, Ang II and/or bradykinin are implicated in inflammation and apoptosis by mechanical ventilation.Keywords
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