NEGATIVE PRESSURE RESPIRATION, WATER DIURESIS AND NATRIURESIS IN NORMOTENSIVE, HYPERTENSIVE AND PREHYDRATED NORMOTENSIVE SUBJECTS *

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Abstract
In normotensive subjects, breathing against continuous negative pressure elicits a moderate water diuresis. The present study was designed to determine whether or not negative pressure breathing is an effective natriuretic stimulus in hypertensive subjects and in prehydrated normotensive subjects. The diuretic effect of negative pressure breathing was demonstrable in hydropenic hypertensive subjects and it was exaggerated in prehydrated normotensive subjects who were also in the hydropenic state, but in neither group did negative pressure breathing induce a natriuretic response. It is concluded that, under conditions of the study, negative pressure breathing is not a stimulus that leads to excessive natriuresis in subjects (hypertensive and prehydrated) otherwise predisposed to natriuresis.