The chemotherapy of rodent malaria XXXIII

Publisher Website
Google Scholar
Abstract
The activity of some chloroquine, mepacrine and amodiaquine analogues in inducing autophagic vacuole formation (pigment clumping) in vitro in erythrocytic stages of Plasmodium berghei was examined. Modifications of the quinoline or acridine nucleus have more influence than side chain modifications (other than replacement of a nitrogen atom) on clumping activity. The aromatic nitrogen atom is vitally important in the drug-receptor interaction, and severe spatial restrictions are imposed here. It is probable that quinine-like drugs interact with the same receptor in a fundamentally different way.