Morphology of a Disease With Features of Malignant Lymphoma in Marmosets and Owl Monkeys Inoculated With Herpesvirus saimiri
- 1 February 1970
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 44 (2) , 447-465
- https://doi.org/10.1093/jnci/44.2.447
Abstract
Herpesvirus saimiri induced a malignancy resembling malignant lymphoma in cotton-topped marmosets (Saguinus oedipus) and owl monkeys (Aotus trivirgatus). Marked reticulum cell invasion with associated organ replacement occurred in a variety of tissues, but regularly in the liver, kidney, spleen, lymph nodes, and adrenal. Peripheral blood changes developed in some individuals and were characterized by leukocytosis, lymphocytosis, and the presence of immature lymphocytes, lymphoblasts, and reticulum cells. The malignancy developed in every marmoset or owl monkey inoculated with the virus and resulted in death in 13–48 days.Keywords
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