The Search for the Ultimate Cause of Maleness

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Abstract
From the time of the first studies of human sex-chromosome anomalies it has been clear that sex determination in human beings is largely a function of the presence or absence of a Y chromosome; the Y chromosome is both necessary and sufficient for male development. Exceptions to that rule have been the primary resource for learning what specific genetic information on the Y chromosome is responsible for maleness and how that information diverts the developmental cascade. These questions have been the foci of numerous scientific studies in the past few decades. The paper by Kiel-Metzger et al.1 in the current . . .