Synthesis of DTPA Analogues Derived from Piperidine and Azepane: Potential Contrast Enhancement Agents for Magnetic Resonance Imaging
- 18 October 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 66 (23) , 7745-7750
- https://doi.org/10.1021/jo0106344
Abstract
Two DTPA derivatives (PIP-DTPA and AZEP-DTPA) as potential contrast enhancement agents in MRI are synthesized. The T1 and T2 relaxivities of their corresponding Gd(III) complexes are reported. At clinically relevant field strengths, the relaxivities of the complexes are comparable to that of the contrast agent, Gd(DTPA) which is in clinical use. The serum stability of the 153Gd-labeled complexes is assessed by measuring the release of 153Gd from the ligands. The radiolabeled Gd chelates are found to be kinetically stable in human serum for up to at least 14 days without any measurable loss of radioactivity.Keywords
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