Relation of Choline Oxidase Activity to Dietary Fatty Livers

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Abstract
Liver choline oxidase activity of rats fed a high fat-low choline diet is greatly decreased. It is quite precipitous during the 1st week of this diet, after which it tends to level off. The fat content of the livers of these animals increases progressively for 3 wks. Fatty acids in high concn. greatly inhibit the choline oxidase activity of homogenates prepared from normal livers as well as those prepared from dietary fatty livers. Injns. of choline or betaine 2 hrs. before killing the animals have no effect upon the choline oxidase activity of these livers.

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