A Study of the Role of Protein Synthesis in the Stimulation of Acid Secretion by Gastrin and a Gastrin-like Pentapeptide
- 1 February 1968
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 82 (2) , 416-419
- https://doi.org/10.1210/endo-82-2-416
Abstract
Gastric mucosa of the bullfrog was incubated in vitro in the presence of puromycin and actinomycin D. Stimulation of acid secretion by porcine gastrin and a synthetic gastrin-like pentapeptide was not altered by these inhibitors of protein synthesis. Puromycin but not actinomycin D markedly inhibited the incorporation of C14-leucine into mucosal protein. New protein synthesis is not required for the acid stimulating action of gastrin and related peptides on the isolated bullfrog gastric mucosa.This publication has 3 references indexed in Scilit:
- Effect of puromycin on the membrane changes of the stimulated oxyntic cellExperimental Cell Research, 1966
- Structure–Function Relationships in the Active C-Terminal Tetrapeptide Sequence of GastrinNature, 1965
- Incorporation of C14-labeled Amino Acids into Actinomycin and Protein by Streptomyces antibioticusJournal of Biological Chemistry, 1963