Chemischer Aufbau der Knochensalze bei gesunden und bei rachitischen Tieren.

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Abstract
Four groups of 2 young pigs each were fed a basal diet of 100 gms. maize, 250 gms. barley, 50 gms. bran, 50 gms. powdered meat and 1.8 gms. of NaCl for every 10 kg. of body weight. To the diet of Group I. 10 gms. of CaCO3 and 0.9 gm. vitamin D were added, yielding an "alkaline earth-alkalinity (EA) value" of plus 22.53 mg. equivalent. The diet of Group II was supplemented with 10 gms. CaCO3 alone (EA plus 22.63 mg. equivalent). The animals in these 2 groups remained healthy throughout the duration of the exps. 20 gms. CaCO3 were added to the diet of Group III (EA plus 70.40 mg. equivalent). To the diet of Group IV 8 gms. NaH2PO4 was added (EA minus 70.29 mg. equivalent). The latter 2 groups sustained marked Rickets during the latter part of the expts. The animals were killed by bleeding, and the humeri, femori and tibiae were removed for study. The epiphyses were discarded; the diaphyses were split in half, the spongiosa and fatty marrow being carefully removed. The bones were divided into 3 layers, external or subperiosteal, middle and inner, which were dried separately and then finely powdered. The amts. of ash, Ca, Mg, P and CO2 were ascertained.[long dash]The lowest ash content was found in the external layer mass, the highest in the middle layer, while in the inner layer it was only slightly less than in the middle layer. The corresponding layers of the rachitic bones generally contained less ash and Ca than the normal bones, the difference being most striking in the external layer. While the Ca content of the external layer of the healthy and the alkalotic-rachitic animals coincided quite closely, it was much lower in the acidotic-rachitic animals. The Mg content of all 3 layers showed the same relationship, being somewhat lower in the rachitic bones. The external layer contained the largest amount of P in the normal, a moderate amount in the alkalotic-rachitic and the least in the acidotic-rachitic bones. The CO2 content of the external layer was lowest in the acidotic, highest in the alkalotic animals. The amount of ash, Ca, Mg, P and CO2 for the entire bone was calculated. The tricalcium phosphate and the calcium carbonate content of bone not only form a constant complex union but are present in a mixed form only. No formula of this union is given.

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