Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β
Open Access
- 17 December 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 286 (5448) , 2328-2331
- https://doi.org/10.1126/science.286.5448.2328
Abstract
Mice lacking estrogen receptors α and β were generated to clarify the roles of each receptor in the physiology of estrogen target tissues. Both sexes of αβ estrogen receptor knockout (αβERKO) mutants exhibit normal reproductive tract development but are infertile. Ovaries of adult αβERKO females exhibit follicle transdifferentiation to structures resembling seminiferous tubules of the testis, including Sertoli-like cells and expression of Müllerian inhibiting substance, sulfated glycoprotein-2, andSox9. Therefore, loss of both receptors leads to an ovarian phenotype that is distinct from that of the individual ERKO mutants, which indicates that both receptors are required for the maintenance of germ and somatic cells in the postnatal ovary.Keywords
This publication has 32 references indexed in Scilit:
- Chronically Elevated Luteinizing Hormone Depletes Primordial Follicles in the Mouse Ovary1Biology of Reproduction, 1997
- Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birdsNature Genetics, 1996
- The Comparative Cell Biology of Accessory Somatic (or Sertoli) Cells in the Animal TestisPublished by Elsevier ,1995
- Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9Cell, 1994
- Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.Proceedings of the National Academy of Sciences, 1993
- Expression of estrogen receptor gene in mouse oocyte and during embryogenesisMolecular Reproduction and Development, 1992
- Production of Müllerian‐inhibiting Substance (MIS) and Sulfated Glycoprotein‐2 (SGP‐2) Associated with Testicular Differentiation in the XX Mouse Gonadal GraftaAnnals of the New York Academy of Sciences, 1991
- Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substanceNature, 1990
- Expression of the gene for anti-Mullerian hormoneReproduction, 1990
- Germ cell deficiency causes testis cord differentiation in reconstituted mouse fetal ovariesJournal of Experimental Zoology, 1990