Lipoprotein patterns in diet, sulphonylurea, and insulin treated diabetics

Publisher Website
Google Scholar
Abstract
In order to study the lipoprotein pattern in diabetes mellitus, plasma lipoproteins were isolated by rate zonal centrifugation in 12 control subjects (median fasting blood glucose level: 80 mg/dl (range: 74–86)), 14 diabetic patients treated by diet alone 104 mg/dl (76–153), 27 patients treated by diet plus insulin (180 mg/dl (106–404)), and 32 patients treated by diet plus sulphonylurea [178 mg/dl (103–361)]. No significant differences of median relative body weight existed between the four groups. Neither the diabetic group on diet alone nor the insulin-treated group differed significantly from control subjects with respect to lipid and lipoprotein concentrations. Diabetics treated with diet plus sulphonylurea, however, differed significantly from the control group with regard to the following parameters (median and range); plasma triglycerides (210 [75–620) mg/dl; p2 (HDL2) [51 (12–121) mg/dl; p2 (r = -0.29, p2 (r = -0.89, p3 concentration. It is concluded that the deranged lipoprotein metabolism in diabetes mellitus may be better controlled by insulin than by sulphonylureas.