The febrile responses in rabbits and rats to leucocyte pyrogens of different species.

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Abstract
The effects on body temperature of rats and rabbits of leukocyte pyrogen derived from the blood of rat, rabbit, ox, pig and baboon were studied. In the rabbit i.v. injections (3.5 ml) of solutions containing leukocyte pyrogen derived from ox, pig and rabbit blood produced fevers with short latencies; no fevers resulted from injections of similar solutions derived from rat or baboon blood. In the rat i.p. injections (2.0 ml) of solutions containing leukocyte pyrogen derived from ox blood caused a fever, while pig leukocyte pyrogen produced a marked hypothermia. Netiher rabbit, baboon, nor rat leukocyte pyrogen had any significant effect on rectal temperature of the rats. There is a variability of response in the rat and the rabbit to injection of leukocyte pyrogen of different species; leukocyte pyrogen may be species specific.

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