Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders
- 29 January 2009
- journal article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 92 (3) , 247-251
- https://doi.org/10.1111/j.1600-0404.1995.tb01696.x
Abstract
In this study levels of neuron-specific enolase (NSE), S-100 protein (S-100) and myelin basic protein (MBP) in cerebrospinal fluid (CSF) of children and adults with distinct neurological disorders were examined. A previous study from our department demonstrated age related reference values for these brain-specific proteins in CSF. The median concentration level of the 3 proteins in 17 different neurological disease groups versus the reference group was compared. Significantly higher MBP values were observed in patients with multiple sclerosis (MS), cerebrovascular accident (CVA), metabolic disorder and infection. Furthermore, significantly higher values were demonstrated for S-100 in CVA and for NSE in metabolic diseases. In CVA, the NSE and S-100 values were significantly related with MBP values, whereas in MS the NSE and S-100 were not related with MBP values.Keywords
This publication has 20 references indexed in Scilit:
- CSF myelin basic protein, IgG and IgM levels in 101 MS patients before and after treatment with high-dose intravenous methylprednisoloneActa Neurologica Scandinavica, 1992
- Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction.Stroke, 1991
- S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system.Stroke, 1987
- Neuron Specific Enolase, A Clinically Useful Marker for Neurons and Neuroendocrine CellsAnnual Review of Neuroscience, 1987
- Myelin basic protein and creatine kinase BB isoenzyme as CSF markers of intracranial tumors and strokeActa Neurologica Scandinavica, 1986
- Determination in human cerebrospinal fluid of glial fibrillary acidic protein, S-100 and myelin basic protein as indices of non-specific or specific central nervous tissue pathologyClinica Chimica Acta; International Journal of Clinical Chemistry, 1986
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983
- Assessment of damage to the central nervous system by determination of S-100 protein in the cerebrospinal fluid.Journal of Neurology, Neurosurgery & Psychiatry, 1982
- A diagnostic index of active demyelination: Myelin basic protein in cerebrospinal fluidAnnals of Neurology, 1980
- Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disordersAnnals of Neurology, 1980