A Regioselective Approach to 5-Substituted-3-amino-1,2,4-triazines
- 23 May 2003
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (13) , 2271-2274
- https://doi.org/10.1021/ol034602+
Abstract
Nucleophilic displacement of readily available alpha,alpha-dibromoketones with excess morpholine gave the corresponding ketoaminals, which upon condensation with aminoguanidine in MeOH in the presence of AcOH afforded 5-substituted-3-amino-1,2,4-triazines in >95% regioselectivity and 45-76% isolated yield. [reaction: see text]Keywords
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