Toxicological properties of O,O,S‐trialkyl phosphorothioates
- 19 October 1983
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 12 (4-6) , 591-598
- https://doi.org/10.1080/15287398309530451
Abstract
The effect of atropine, 2-pyridine aldoxime methiodide (2-PAM) and several O,O,O-trialkyl phosphorothioates on poisoning of rats by a series of O,O-dimethyl and O,O-diethyl S-alkyl phosphorothioates was investigated. Atropine and 2-PAM successfully protected rats treated with O,O-diethyl S-n-propyl and S-isopropyl phosphorothioates, while the O,O,O-trialkyl phosphorothioates were effective in protecting rats treated with O,O-dimethyl S-methyl and S-ethyl phosphorothioates. O,O-Dimethyl and O,O-diethyl S-isopropyl phosphorothioates also were examined for in vitro and in vivo inhibition of rat plasma, red blood cell and brain cholinesterase. Two different mechanisms, cholinergic and noncholinergic were involved in introxication by the O,O,S-trialkyl phosphorothioates.This publication has 9 references indexed in Scilit:
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