Effect of Viral Double-Stranded RNA on Protein Synthesis in Intact Cells
- 1 February 1973
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 11 (2) , 232-7
- https://doi.org/10.1128/jvi.11.2.232-237.1973
Abstract
The addition of purified, noninfectious, double-stranded RNA of bovine enterovirus, a picornavirus, to intact cells in culture results in a rapid cessation of cellular polypeptide synthesis. This inhibition is specific for host cell protein synthesis since the translation of picornavirus-specific proteins is not affected by the double-stranded viral RNA.Keywords
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