TIRON (SODIUM 4,5-DIHYDROXYBENZENE-1,3-DISULFONATE) AS AN ANTIDOTE FOR ACUTE URANIUM INTOXICATION IN MICE
- 1 January 1981
- journal article
- research article
- Vol. 34 (2) , 351-358
Abstract
Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) administered i.p. antagonized the lethal action of i.p.-induced U (VI) toxicity. Tiron was compared to Na3CaDTPA (sodium calcium diethylenetriaminepentaacetate). The ability of these compounds to detoxify the uranyl ion in simple and complexed form and their efficacy in delayed treatment regimens were determined. Toxicities of the complexes were assessed by the administration of uranyl acetate at levels of 40 or 80 mg/kg complexed at a mol ratio of 3:1 or 2:1 of chelating agent to U, prior to injection, followed by 2 additional doses of chelating agent given 1 and 3 h later at a 10:1 mol ratio of chelating agent to U. Therapy in delayed treatment regimens consisted of 3 injections of antidote given 20 min, 1 h and 3 h, at a 10:1 mol ratio of chelating agent to U, subsequent to an injection of 40 mg/kg uranyl acetate. Survival rates for animals receiving multiple injections of Tiron were enhanced over those receiving Na3CaDTPA. The low inherent toxicity of Tiron make it appropriate for possible clinical application.This publication has 2 references indexed in Scilit:
- Specific Sequestering Agents for the Actinides: 4. Removal of 238 Pu(IV) from Mice by Sulfonated Tetrameric Catechoyl AmidesRadiation Research, 1980
- THE DISTRIBUTION AND EXCRETION OF INJECTED URANIUMJournal of Biological Chemistry, 1948