Additives and Enzyme Stability
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Biocatalysis
- Vol. 1 (3) , 187-196
- https://doi.org/10.3109/10242428809014845
Abstract
The polypeptide chain of an enzyme is folded so that the necessary functional groups are brought together in the active site. Conformational changes may disrupt this arrangement and cause loss of enzymic activity. The effect of soluble additives on the unfolding process is discussed. Additives may be classified as substrates and similar ligands, small uncharged organic molecules, specific and non-specific ionic species, and polymers.Keywords
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