Effects of In Vitro Electrical Stimulation on Enhancement and Suppression of Malignant Lymphoma Cell Proliferation
- 16 January 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 83 (2) , 116-119
- https://doi.org/10.1093/jnci/83.2.116
Abstract
The suppression and enhancement of proliferation of mouse EL4 lymphoma cells varied significantly when the cells were electrically stimulated within a narrow range of low-level direct current With the use of platinum electrodes, the suppression characteristics were observed over a narrow range, or window, of direct currents centered at approximately 17 μA. Enhancement characteristics were observed over a broad range of low-level direct currents (approximately 0.1 to 10 μA). These results indicate that the proliferation of certain eukaryotic cells may be directly controlled by stimulation with low-level direct current. [J Natl Cancer Inst 83:116–119, 1991]Keywords
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