THE EFFECTS OF DIFFERENT HOMOLOGOUS SPLEEN CELL DOSES AND DONOR-RECIPIENT AGES ON THE MORTALITY OF SUBLETHALLY X-IRRADIATED MICE

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Abstract
Early mortality is known to occur in sublethally X-radiated mice following their infusion with homologous spleen cells. In experiments to investigate parameters influencing the phenomenon, BDF1 mice given a standard dose of 675 r were infused with spleen cells from A mice. Appearance of early mortality increased with the size of the splenic inoculum. In other experiments recipient animals of different ages were used and it appeared that aged mice were resistant to the effects of the homologous spleen. Variations in the age of the splenic cell donors failed to modify the end result. It is concluded that the phenomenon of early death depends upon the size of the splenic cell inoculum and the recipient''s age but that it is independent of the age of the spleen donor.

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