Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.
Open Access
- 1 June 1977
- Vol. 39 (6) , 657-660
- https://doi.org/10.1136/hrt.39.6.657
Abstract
Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.This publication has 11 references indexed in Scilit:
- Acute termination of cardiac arrhythmias with intravenous disopyramide.1976
- The effect of disopyramide on in vivo measurement of monophasic action potential in canine heart muscle.1976
- The pharmacokinetics of disopyramide following myocardial infarction with special reference to oral and intravenous dose regimens.1976
- Effects of disopyramide on electrophysiological properties of specialized conduction system in man and on accessory atrioventricular pathway in Wolff-Parkinson-White syndrome.Heart, 1975
- Electrophysiologic effects of the antiarrhythmic agent disopyramide phosphateThe American Journal of Cardiology, 1975
- Classification of antidysrhythmic drugsPharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1975
- Electrophysiological evaluation of disopyramide in manAmerican Heart Journal, 1973
- Class 3 antiarrhythmic action in man. Observations from monophasic action potential recordings and amiodarone treatment.Heart, 1973
- Effects of Disopyramide on Electrophysiological and Mechanical Properties of the HeartJournal of Pharmaceutical Sciences, 1973
- A COMPARISON OF THE ANTIFIBRILLATORY ACTIONS AND EFFECTS ON INTRACELLULAR CARDIAC POTENTIALS OF PRONETHALOL, DISOPYRAMIDE AND QUINIDINEBritish Journal of Pharmacology and Chemotherapy, 1963