Assessment of the level of nutrition. Urinary excretion of aneurin at varying levels of intake

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Abstract
On a basal B1-deficient diet the excretion of B1 (method of Wang and Harris) in 3 subjects fell rapidly to a steady value maintained for some time. With graded doses a constant level of excretion was attained with each fresh level of intake, increasing only slightly at first but rapidly when the intake exceeded 1200 [gamma]. On the reputed requirement of 900 [gamma] the avg. excretion (4 subjects) was 137 to 233 [gamma]. The excretion at lower levels may be at the expense of the body''s reserves, and the level at which rapid excretion begins may be an indication of the requirements. The rapidity with which the excretion adjusts itself to changes in the intake must be taken into account in assessing the "level of nutrition." Further results of tost doses are necessary to determine this level. The % excretion at different levels varied individually, owing possibly to differences in rate of absorption or in kidney threshold. Exercise and variations in the amt. of carbohydrate and fat in the diet also affected excretion.