β-Cell death during progression to diabetes
Top Cited Papers
- 1 December 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 414 (6865) , 792-798
- https://doi.org/10.1038/414792a
Abstract
The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.Keywords
This publication has 95 references indexed in Scilit:
- Coupling Endoplasmic Reticulum Stress to the Cell Death ProgramJournal of Biological Chemistry, 2001
- Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell SurvivalPublished by Elsevier ,2001
- Monitoring gene expression of TNFR family members by β-cells during development of autoimmune diabetesEuropean Journal of Immunology, 2000
- Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and β-islet cellsEuropean Journal of Immunology, 1999
- Pancreatic β Cell–specific Expression of Thioredoxin, an Antioxidative and Antiapoptotic Protein, Prevents Autoimmune and Streptozotocin-induced DiabetesThe Journal of Experimental Medicine, 1998
- Programmed Cell Death in Animal DevelopmentCell, 1997
- Sensitivity of human pancreatic islets to peroxynitrite‐induced cell dysfunction and deathFEBS Letters, 1996
- Following a diabetogenic T cell from genesis through pathogenesisCell, 1993
- Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic miceCell, 1991
- Intolerable secretion in tolerant transgenic miceNature, 1988