Inhibition by Neurotoxic Phospholipases A2 of Synaptosomal Uptake of γ‐Aminobutyric Acid
- 1 January 1981
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (1) , 310-312
- https://doi.org/10.1111/j.1471-4159.1981.tb02412.x
Abstract
A comparison has been made of the abilities of several neurotoxic and nontoxic phospholipases A2 from snake venoms to inhibit the intake of gamma-aminobutyric acid into synaptosomes from rat cerebral cortex. The neurotoxic phospholipase A2 inhibited GABA uptake more than the nontoxic enzymes did. However, there was a poor correlation between the measured specific enzyme activity of a phospholipase A2 and its ability to inhibit the uptake of GABA.Keywords
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