HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
- 1 October 1987
- journal article
- Published by Springer Nature in Nature
- Vol. 329 (6140) , 599-604
- https://doi.org/10.1038/329599a0
Abstract
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.Keywords
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