Synthesis of pyrazole analogues of isoaptazepine
- 1 December 1992
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 29 (7) , 1851-1854
- https://doi.org/10.1002/jhet.5570290729
Abstract
The synthesis of the novel tetracyclic rings 5 and 6 is described starting from 4‐cyano‐1‐methyl‐5(1H‐pyrrol‐1‐yl)‐1H‐pyrazole and its 3‐(1H‐pyrrol‐1‐yl)‐ isomer, respectively. The pathway employed is based on a one‐pot double annelation reaction involving the transformation of 13 into the required tetracyclic derivative 16. Lithium aluminum hydride/sulfuric acid reduction of the last compound furnished 5. A similar way was used for the synthesis of 6 by cyclization of 20.Keywords
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