A HUMAN MALIGNANT CELL LINE ESTABLISHED FROM ASCITES OF PATIENT WITH EMBRYONAL CARCINOMA OF OVARIUM
- 8 January 1975
- journal article
- Published by Wiley in Acta Pathologica Japonica
- Vol. 25 (1) , 89-98
- https://doi.org/10.1111/j.1440-1827.1975.tb00152.x
Abstract
In our attempts at establishing a cancer cell line from various ascites of cancer bearing patients, a cell line was successfully established from the ascites of a 63-year-old female with primary ovarian tumor (embryonal carcinoma). Histological findings of the peritoneum, due to metastasis, appeared to be cystadenocarcinoma, revealing the differentiation to non-epithelial cells which formed coarse networks and fibers, and morphologic changes of tissue cultures also reflected such histologic findings. At present the subculture has reached the 95th population doubling level, and cultured cells have assumed the morphology of mesothelial cells or fibroblasts with about 50 chromosomes. As a human malignant cell line, it is useful for the study of human malignant tumor cell.Keywords
This publication has 2 references indexed in Scilit:
- CELL RECOGNITION AND PHAGOCYTOSIS OF SV40 TRANSFORMED CELLActa Pathologica Japonica, 1973
- Embryonal carcinoma of the ovaryCancer, 1962