The postabsorptive urinary hydroxyproline (Spot-HYPRO) in patients with multiple myeloma
- 1 August 1981
- Vol. 48 (3) , 783-787
- https://doi.org/10.1002/1097-0142(19810801)48:3<783::aid-cncr2820480321>3.0.co;2-h
Abstract
The simple postabsorptive urine hydroxyproline (Spot-HYPRO) with dialyzable and non-dialyzable (ND) fractions was measured in 28 patients with multiple myeloma. Myeloma patients with bone disease had higher total Spot-HYPRO and dialyzable fractions (P < 0.001) than myeloma patients without bone disease or controls. The ND fraction of the Spot-HYPRO was elevated in myeloma patients with renal disease as compared with myeloma patients without renal disease and controls (P < 0.01). Follow-up studies of ten myeloma patients demonstrated a close correlation between Spot-HYPRO and the dialyzable fraction and the evolution of bone disease. The Spot-HYPRO and its dialyzable fraction constitute a simple, inexpensive, and accurate test for the diagnosis and follow-up of the skeletal disease in patients with multiple myeloma.This publication has 23 references indexed in Scilit:
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