A Chiral Acyclic Bis-allylic Compound as a Dienophile for Asymmetric Diels-Alder Reactions
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (11) , 819-820
- https://doi.org/10.1055/s-1991-20889
Abstract
A chiral bis-allylic compound, diethyl (4S,5S)-4, 5-bis(tert-butyldimethylsilyloxy)-2,6-octadienedioate, has been used as a chiral dienophile to give [4+2] cycloadducts with several dienes in very high diastereomeric excess (>99%). One of the cycloadducts prepared from cyclopentadiene has led to aminobicyclo[2.2.1]heptane derivatives which are closely related to the TXA2 antagonist family.Keywords
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