Inhibitory effect of 2-(2-fluoro-4-biphenylyl) propionic acid (Flurbiprofen) on prostaglandin synthesis

1 January 1976

journal article
research article
Published by Japanese Pharmacological Society in Folia Pharmacologica Japonica

Vol. 72 (8) , 1025-1031
https://doi.org/10.1254/fpj.72.1025

Abstract

Inhibitory effects of 2-(2-fluoro-4-biphenylyl) propionic acid (Flurbiprofen, FP-70) on prostaglandin (PG) synthesis and PG activity were investigated in vivo and in vitro. FP-70 at 0.64 .mu.M showed 50% inhibitory effect on PG synthesis from arachidonic acid in guinea pig lung cell-free homogenate. PGE2 and PGF2.alpha. were separated by TLC. FP-70 strongly inhibited synthesis of PGE2 and PGF2.alpha. at 3.mu.M, but inhibited more extensively the synthesis of PGE2 than that of PGF2.alpha. 0.3.mu.M. FP-70 at 1 mg/kg, p.o.,[orally] inhibited mostly arachidonic acid potentiation of carrageenan-induced edema in the rat paw, but did not inhibit PGE2 potentiation of carrageenin-induced edema. FP-70 did not inhibit the contraction of rat stomach strip induced by PGE2. FP-70 apparently inhibited PG synthesis but not PG activity. Potent anti-inflammatory action of FP-70 may be the result of inhibition of PG synthesis.

This publication has 0 references indexed in Scilit: