Tetrahydrofolate-Dependent Enzymes and Dihydrofolic Reductase in Human Tissues

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Abstract
Summary. The activity levels of the tetrahydrofolate-dependent enzymes and of dihydrofolate reductase were determined in human tissues. The highest activity of H4 folate-dependent enzymes has been documentated in normal human liver; the lowest, in skeletal muscle. Dihydrofolic reductase was detected in liver, kidney, gastric mucosa, normal skin (incostant), psoriatic epidermis and in stimulated bone marrow. Enzyme activity was also present in leukaemic leukocytes. Enzyme patterns similar to those of normal tissues of adults were also found in human embryos.

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