PREVENTION OF ABNORMALITIES PRODUCED BY 2 ORGANO-PHOSPHORUS PESTICIDES (PARATHION AND BIDRIN) IN QUAIL EMBRYOS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 65  (1) , 1-15
Abstract
When quail embryos, injected with bidrin at the unincubated stage, were treated with nicotinamide, beak and leg abnormalities were prevented, but niacin had no beneficial effect on the axial deformities caused by both parathion and bidrin. Vertebral defects were greatly reduced by giving pralidoxine, an antidote known and used in organophosphorus intoxications. But this compound has no effect on beak and leg damage caused by bidrin. Two other cholinesterase reactivators, diacetylmonoxime and monoisonitrosoacetone had no effect on organophosphorus abnormalities and had no antiteratogenic action either on the beak and legs or on the vertebral column. The multiple causes of teratogenic effects induced by organophosphorus compounds were evident. Both aspects of teratogenesis, one related to the nicotinamide level and the other related to the physiology of the cholinergic system, are discussed.

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