Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in Escherichia coli Overexpressing RND Efflux Pumps
Open Access
- 1 February 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (2) , 849-852
- https://doi.org/10.1128/aac.49.2.849-852.2005
Abstract
Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.Keywords
This publication has 9 references indexed in Scilit:
- Efflux-mediated multiresistance in Gram-negative bacteriaClinical Microbiology & Infection, 2004
- Efflux-Mediated Drug Resistance in BacteriaDrugs, 2004
- Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolatesBiochemical Journal, 2003
- 3-Arylpiperidines as potentiators of existing antibacterial agentsBioorganic & Medicinal Chemistry Letters, 2001
- Enhanced Expression of the Multidrug Efflux Pumps AcrAB and AcrEF Associated with Insertion Element Transposition in Escherichia coli Mutants Selected with a FluoroquinoloneAntimicrobial Agents and Chemotherapy, 2001
- Antibiotic Susceptibility Profiles of Escherichia coli Strains Lacking Multidrug Efflux Pump GenesAntimicrobial Agents and Chemotherapy, 2001
- Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination TherapyAntimicrobial Agents and Chemotherapy, 2001
- Non-Target Gene Mutations in the Development of Fluoroquinolone Resistance in Escherichia coliAntimicrobial Agents and Chemotherapy, 2000
- Inhibitors of Efflux Pumps in Pseudomonas aeruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial LevofloxacinJournal of Medicinal Chemistry, 1999