Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.
- 1 November 1993
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (21) , 10125-10129
- https://doi.org/10.1073/pnas.90.21.10125
Abstract
We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon up-stream of the usual transcription initiation site. This isoform, embryonic-neonatal MBP (E-MBP), is expressed at the protein level in the embryonic nervous system at a time when other MBP isoforms are not detected. In addition to the central and peripheral nervous systems of the embryo and neonate, the thymus, spleen, and testes also express E-MBP at the protein level. The expression of E-MBP in cell types distinct from the nervous system strongly suggests that this MBP isoform has a role apart from the formation of myelin.Keywords
This publication has 25 references indexed in Scilit:
- Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.Journal of Biological Chemistry, 1993
- Developmental profile and differential localization of mRNAs of myelin proteins (MBP and PLP) in oligodendrocytes in the brain and in cultureDevelopmental Brain Research, 1989
- Regional expression of myelin protein genes in the developing mouse brain: In situ hybridization studiesJournal of Neuroscience Research, 1988
- A role for platelet-derived growth factor in normal gliogenesis in the central nervous systemCell, 1988
- Thyroid hormone induction of keratin genes: a two-step activation of gene expression during development.Genes & Development, 1987
- The Molecular Basis of the Sparse Fur Mouse MutationScience, 1987
- Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotypeCell, 1987
- Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.Proceedings of the National Academy of Sciences, 1987
- Alternative splicing accounts for the four forms of myelin basic proteinCell, 1985
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979