Synthesis of Calystegine B2 Analogs by Tandem Tautomerization-Intramolecular Glycosylation of Thioureidosugars

Abstract
Ring-modified analogs of calystegine B2, a powerful glycosidase inhibitor of the polyhydroxy-nor-tropane series, have been prepared in one-pot reaction from thiourea-carbohydrate precursors via a tandem tautomerization-intramolecular glycosylation process.

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