ENZYME INHIBITION BY STEROID ANAESTHETIC AGENTS DERIVED FROM PROGESTERONE
- 1 May 1985
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 57 (5) , 512-514
- https://doi.org/10.1093/bja/57.5.512
Abstract
The anesthetic potency of steroids related by metabolism to progesterone shows marked variation with small changes in structure [in mice]. The same group of substances have varying abilities to inhibit bacterial luciferase competitively, although there is no correlation between anesthetic and inhibition potency. Closely related hydrophobic steroids are able to interfere with the catalytic activity of an enzyme selectively and, by inference, suggest that differences in anesthetic potency could be a consequence of selective differences in ability to interact with a target protein.This publication has 3 references indexed in Scilit:
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- General anaesthetics and bacterial luminescence II. The effect of diethyl ether on the in vivo light emission of Vibrio fischeriProceedings of the Royal Society of London. B. Biological Sciences, 1976
- CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS1Endocrinology, 1942