Effects of modification of intracellular cyclic AMP levels on the immediate hypersensitivity reaction in vivo

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Abstract
The effects of agents that elevate endogenous cyclic AMP levels on the progression of a reverse passive Arthus reaction in the pleural cavity of rats was studied. Three hours after the onset of the reaction a marked reduction in histamine release was observed which correlated well with increases in cellular cyclic AMP concentration. The results at 6 h suggested a relationship between cyclic AMP and leukocyte PGE [prostaglandin E], the latter being reduced dramatically in the cells and in the fluid exudate by agents that elevate cyclic AMP. Cyclic AMP may play an important regulatory role in vivo in the release of inflammatory mediators from leukocytes.
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