Typing of Human Rhinoviruses Based on Sequence Variations in the 5' Non-coding Region
- 1 November 1989
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 70 (11) , 3111-3116
- https://doi.org/10.1099/0022-1317-70-11-3111
Abstract
Summary Unambiguous assignment of restriction enzyme patterns to six individual serotypes of human rhinovirus was accomplished after amplification of a 380 bp DNA fragment derived from the 5′ non-coding region. This was possible even though serotypes 1A and 1B and serotypes 2 and 49 differed only at 10 and 15 positions respectively. The method utilizes the conserved and variable components of this part of the genome and provides the basis for a simple and rapid method for typing of human rhinoviruses.Keywords
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