B Non-Hodgkin's Lymphoma in a Haemophilia Patient with Idiopathic CD4+ T-lymphocytopenia
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 21 (1-2) , 177-180
- https://doi.org/10.3109/10428199609067597
Abstract
We report here a case of an HIV-uninfected, anti-hepatitis C virus (HCV) positive hacmophiliac, who was transfused with blood and intermediate purity factor VIII concentrates. Since 1988, a progressive decline in the CD4+ T-cell count was recorded, and in 1993 a B-cell non-Hodgkin's lymphoma (B-NHL) was diagnosed. The morphological appearance of the tumor with features of intermediate/mantle zone lymphoma, and the absence of EBV sequences within the tumor, ruled out the occurrence of a typical “opportunistic” lymphoma. However it is possible that the blood product therapy and its infectious complications may have played a role on immune function impairment.Keywords
This publication has 18 references indexed in Scilit:
- Lymphoproliferative disease in human peripheral‐blood‐mononuclear‐cell‐injected scid mice. II. Role of host and donor factors in tumor generationInternational Journal of Cancer, 1994
- Pathogenesis of AIDS lymphomasAIDS, 1994
- CD4+ T-Lymphocytopenia without HIV Infection -- No Lights, No Camera, Just FactsNew England Journal of Medicine, 1993
- Unexplained Opportunistic Infections and CD4+ T-Lymphocytopenia without HIV Infection -- An Investigation of Cases in the United StatesNew England Journal of Medicine, 1993
- Quantitative Oropharyngeal Epstein-Barr Virus Shedding in Renal and Cardiac Transplant Recipients: Relationship to Immunosuppressive Therapy, Serologic Responses, and the Risk of Posttransplant Lymphoproliferative DisorderThe Journal of Infectious Diseases, 1992
- Acquired immunodeficiency without evidence of infection with human immunodeficiency virus types 1 and 2The Lancet, 1992
- Immunological studies in HIV seronegative haemophiliacs: relationships to blood product therapyBritish Journal of Haematology, 1992
- Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction.Journal of Clinical Pathology, 1990
- First Case in Italy of Fatal AIDS in a Hemophiliac1Acta Haematologica, 1986
- Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry & Cytochemistry, 1981