Nitric Oxide–Releasing Drugs
- 1 April 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 43 (1) , 97-123
- https://doi.org/10.1146/annurev.pharmtox.43.100901.140226
Abstract
Pharmacological compounds that release nitric oxide (NO) have been useful tools for evaluating the broad role of NO in physiology and therapeutics. NO deficiency has been implicated in the genesis and evolution of several disease states. Both medical needs and commercial opportunities have fostered attempts to modulate NO in the human body for therapeutic gain. Strategies for NO modulation encompass antiinflammatory, sexual dysfunction, and cardiovascular indications. Apart from newly developed drugs, several commonly used cardiovascular drugs exert their beneficial action, at least in part, by modulating the NO pathway. This review discusses the fundamental pharmacological properties and mechanisms of action of NO-releasing drugs. Some of these compounds may enter in the clinical arena providing important therapeutic benefits in human diseases.Keywords
This publication has 101 references indexed in Scilit:
- Oxidation-Sensitive Transcription Factors and Molecular Mechanisms in the Arterial WallAntioxidants and Redox Signaling, 2001
- Vasomotor effects of L- and D-arginine in stenotic atheromatous coronary plaqueHeart, 2001
- A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erectionInternational Journal Of Impotence Research, 2001
- Endothelial Nitric Oxide Synthase-Dependent Cerebral Blood Flow Augmentation by L-Arginine After Chronic Statin TreatmentJournal of Cerebral Blood Flow & Metabolism, 2000
- The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertensionBritish Journal of Clinical Pharmacology, 1999
- A HMG-CoA Reductase Inhibitor Improved Regression of Atherosclerosis in the Rabbit Aorta without Affecting Serum Lipid Levels: Possible Relevance of Up-Regulation of Endothelial NO Synthase mRNABiochemical and Biophysical Research Communications, 1999
- Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in ratsLife Sciences, 1996
- Oxidized lipoproteins and nitric oxideCurrent Opinion in Lipidology, 1996
- Role of nitrates in acute myocardial infarctionThe American Journal of Cardiology, 1992
- Guanylate cyclase activation by nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediatesBiochemical and Biophysical Research Communications, 1980