THROMBOSIS INDUCED INVIVO IN MESENTERIC-ARTERY OF RATS - ELECTRON-MICROSCOPIC STUDY OF INITIAL PHASES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (6) , 722-732
Abstract
Local thrombosis was initiated in vivo by applying a weak electric current to the mesenteric artery of rats. The thrombi adhered to areas of arterial wall exhibiting endothelial cell loss and muscle cell damage. They showed no tendency to sustained growth and contained large amounts of vaguely fibrillary substance that enmeshed platelet aggregates and infiltrated the denuded subendothelial layer. The subsequent local administration of dilute ADP led to brisk platelet aggregation and rapid increase in size of the thrombi. The large thrombotic masses disappeared as soon as the administration of ADP was stopped, leaving behind small remnants which, like the initial thrombi, were predominantly composed of enmeshing substance and could be stimulated to renewed growth by resuming the administration of ADP. The enmeshing substance apparently played a major role in the stability and cohesion of early thrombi which did not yet contain fibrin. It conceivably was made up of fibrin monomers.